![]() ![]() Since then, millions of Americans have never been vaccinated. Until 1971, when the Advisory Committee on Immunization Practices recommendation for vaccination ended, most American infants were routinely vaccinated. These studies have raised questions about the safety and adverse-event profile of the vaccine for individuals naive to vaccinia virus vaccine (hereafter, “vaccinia-naive”). Studies are being planned or are underway that involve the use of new CCSVs in both children and adults. Because it was prepared from calf lymph, Dryvax can no longer be manufactured without extensive safety testing of livestock and US Food and Drug Administration approval, and only old stocks remain. Dryvax production and distribution to civilians ceased in 1983 because of lack of need. ![]() Live vaccinia virus vaccines have been used in the past, including Dryvax (Wyeth Laboratories). ![]() Because there is a risk that the smallpox virus will be used as a bioterrorism weapon, new cell-cultured smallpox vaccines (CCSVs) are being developed. ![]()
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